Longer human lifespan linked to these genes, new research shows

A new study describing the link has been published in the journal Genome research.

Genes that could extend the lifespan of small organisms, such as fruit flies living ten percent longer, have now been discovered by researchers at University College London (UCL) to demonstrate a similar effect in man. Genes are linked to the creation of proteins in our cells and seem to be an example of antagonistic pleiotropywhere the genes that help us at the beginning of life and until procreation are selected by evolution, despite the eventual shortening of our lives.

“We have already seen, through extensive previous research, that inhibiting certain genes involved in making proteins in our cells can extend the lifespan of model organisms such as yeast, worms and flies. However, in humans, loss of function of these genes has been shown to cause diseases, such as developmental disorders known as ribosomopathies.Here, we found that inhibition of these genes can also increase longevity in people, perhaps because they are more helpful early in life before causing problems late in life,” said co-lead author Dr Nazif Alic of the Institute. of Healthy Aging from UCL.

The researchers used genetic data from previous studies of 11,262 people who lived a very long time, at ages above the 90th percentile for their cohort. They found genes related to two RNA polymerase enzymes, Pol I and Pol III, and certain ribosomal protein genes that had reduced activity and were correlated with a likelihood of living longer.

They also found that the increase in longevity went beyond associations with a specific age-related disease. This research provides evidence that drugs such as rapamycin, which works to inhibit Pol III, can help promote a healthy lifespan.

You can read more of the study here.

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